Mei He, Ph.D.
Associate Professor
About Mei He
Dr. He has strong research expertise in extracellular vesicles and exosomes -mediated therapeutic delivery and biomarker discovery. She is named as the National Academy of Inventors Senior Member, the Board advisor of Gordon and Betty Moore Foundation and The Moore Inventor Fellowship review committee, and the Editorial Board Advisor for journal of Lab on Chip (LOC), also the Editorial Board member of Pharmaceutics and AAPS Taxonomy Committee. She received the NIH Maximizing Investigator’s Research Award for Early-Stage Investigators in 2019, and the LOC Emerging Investigator Award in 2019. The multiple publications from her research group on exosome-based cancer research received the Most Downloaded Articles of 2016 (LOC), the Featured Cover Story of 2018 (LOC), Technology Readers Choice Award of 2018 (SLAS), and Top 100 Read Articles of 2019 (Scientific Reports from Nature Publishing Group). Her recent publications on extracellular vesicles and exosomes have appeared in the journal of Nature Biomedical Engineering, the Journal of Extracellular Vesicles, and the Nature Communications Biology. Her research brings in novel microfluidic and nanotechnology for differentiating, isolating, and intravesicular loading exosomes precisely, which presents a new way for developing precision medicine. Her research innovation leads to more than 20 pending and issued patents, and she is also the founder of Clara Biotech Inc. and ExoDeL Inc.
Related Links:
Accomplishments
Outstanding Reviewers
2020
·
Lab on a Chip – The Royal Society of Chemistry
LOC Emerging Investigator
2019
·
Royal Society of Chemistry
NIH Maximizing Investigator's Research Award for Early Stage Investigators
2019
·
National Institutes of Health
Outstanding Reviewer for Lab on Chip
2018
·
Royal Society of Chemistry
Reader Choice Award
2018
·
Society for Laboratory Automation and Screening
New Faculty Award
2017
·
Kansas State University
Travel Award for NIH-IEEE Strategic Conference
2016
·
Johnson Cancer Research Center
Ingenuity Central Kansas Innovator
2016
·
Kansas State University
NSF CAREER Workshop Travel Award
2014
·
National Science Foundation
Auxiliary Award
2013
·
University of Kansas Medical Center
CASSS Travel Award for the 26th International Symposium on MicroScale Bioseparations
2011
·
CASSS
NSF ADVANCE Future Faculty Workshop Travel Award
2011
·
National Science Foundation
Final list, California Institute for Quantitative Bioscience (QB3) Distinguished Fellow The University of California, Berkeley, USA
2008
·
California Institute for Quantitative Bioscience
Mary Louise Imrie Graduate Student Award
2007
·
University of Alberta, Canada
Teaching Profile
Courses Taught
2020-2023
PHA5176 Drug Delivery Systems
2021-2024
PHA7979 Advanced Research
2021
PHA6894 Introduction to Graduate Studies
2021,2023
PHA5930 Sem Pharm Research
2021-2024
PHA6910 Supervised Research
2022-2024
PHA6416 Pharmaceutical Analysis I
2022-2023
PHA6740 Fundamentals of Grant Writing in the Pharmaceutical Sciences
2023-2024
PHA6183 Pharmaceutical Gene Delivery
2023
PHA5878C Pt Care 3: Cv and Pulm
2023-2024
PHA7980 Research for Doctoral Dissertation
2024
PHA4912 Undergraduate Research in Pharmaceutics
Research Profile
Dr. He’s research focuses on precise definition and control of immunity at the molecular level to tissue level, via extracellular vesicles and exosomes -mediated delivery and biological programming strategies, which can be employed in advancing cancer immunotherapy, regenerative medicine, and precision therapeutics. The long-standing interest is to understand immunity communication and delivery for translating into novel therapeutics and treatments against cancers, autoimmune diseases, and infectious diseases which immune responses are the central player.
Open Researcher and Contributor ID (ORCID)
0000-0001-5316-9326
Areas of Interest
- 3D Printing and Biomaterials
- Cancer Immunotherapy
- Extracellular Vesicles and Exosomes for Biological Programming and Nanodelivery
- Microfluidic organ on chip
- Regenerative and Precision Therapeutics
Publications
2024
Understanding molecular characteristics of extracellular vesicles derived from different types of mesenchymal stem cells for therapeutic translation
Extracellular Vesicle.
3
[DOI] 10.1016/j.vesic.2024.100034.
2023
Enhancing the Cellular Production of Extracellular Vesicles for Developing Therapeutic Applications
Pharmaceutical Research.
40(4):833-853
[DOI] 10.1007/s11095-022-03420-w.
[PMID] 36319886.
2023
Towards artificial intelligence-enabled extracellular vesicle precision drug delivery
Advanced Drug Delivery Reviews.
199
[DOI] 10.1016/j.addr.2023.114974.
2022
Advanced Biomaterials for Cell-Specific Modulation and Restore of Cancer Immunotherapy
Advanced Science.
9(16)
2022
Light‐induced high‐efficient cellular production of immune functional extracellular vesicles
Journal of Extracellular Vesicles.
11(3)
[DOI] 10.1002/jev2.12194.
[PMID] 35230743.
2022
Nano pom-poms prepared exosomes enable highly specific cancer biomarker detection
Communications Biology.
5(1)
[DOI] 10.1038/s42003-022-03598-0.
[PMID] 35787656.
2021
Biologically Enhanced Starch Bio-Ink for Promoting 3D Cell Growth
Advanced Materials Technologies.
6(12)
[DOI] 10.1002/admt.202100551.
[PMID] 34926789.
2021
Development of surface engineered antigenic exosomes as vaccines for respiratory syncytial virus.
Scientific reports.
11(1)
[DOI] 10.1038/s41598-021-00765-x.
[PMID] 34725399.
2021
Extracellular Vesicles as an Advanced Delivery Biomaterial for Precision Cancer Immunotherapy.
Advanced healthcare materials.
[DOI] 10.1002/adhm.202100650.
[PMID] 34197051.
2021
Isolation of sensory hair cell specific exosomes in human perilymph.
Neuroscience letters.
764
[DOI] 10.1016/j.neulet.2021.136282.
[PMID] 34619343.
2021
Remote Sensing and Remote Actuation via Silicone–Magnetic Nanorod Composites
Advanced Materials Technologies.
6(6)
2021
Remote-Controlled 3D Porous Magnetic Interface toward High-Throughput Dynamic 3D Cell Culture
ACS Biomaterials Science & Engineering.
7(9):4535-4544
[DOI] 10.1021/acsbiomaterials.1c00459.
[PMID] 34468120.
2021
Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery.
Pharmaceutics.
13(1)
[DOI] 10.3390/pharmaceutics13010122.
[PMID] 33477972.
2021
Using Spheroids as building blocks towards 3D bioprinting of tumor microenvironment
International Journal of Bioprinting.
7
2019
3D cell culture stimulates the secretion of in vivo like extracellular vesicles.
Scientific reports.
9(1)
[DOI] 10.1038/s41598-019-49671-3.
[PMID] 31506601.
2019
3D-printing enabled micro-assembly of a microfluidic electroporation system for 3D tissue engineering
Lab on a Chip.
19(14):2362-2372
[DOI] 10.1039/c9lc00046a.
[PMID] 31214669.
2019
Microfluidic on-demand engineering of exosomes towards cancer immunotherapy
Lab on a Chip.
19(10):1877-1886
[DOI] 10.1039/c8lc01279b.
[PMID] 31044204.
2019
Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip.
Nature biomedical engineering.
3(6):438-451
[DOI] 10.1038/s41551-019-0356-9.
[PMID] 31123323.
2018
Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics
Lab on a Chip.
18(12):1690-1703
[DOI] 10.1039/c8lc00246k.
[PMID] 29780982.
2016
3D printed auto-mixing chip enables rapid smartphone diagnosis of anemia.
Biomicrofluidics.
10(5)
[PMID] 27733894.
2016
A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis.
Lab on a chip.
16(3):489-96
[DOI] 10.1039/c5lc01117e.
[PMID] 26645590.
2016
Microfluidic Exosome Analysis toward Liquid Biopsy for Cancer.
Journal of laboratory automation.
21(4):599-608
[DOI] 10.1177/2211068216651035.
[PMID] 27215792.
2016
Ultrasensitive microfluidic analysis of circulating exosomes using a nanostructured graphene oxide/polydopamine coating.
Lab on a chip.
16(16):3033-42
[DOI] 10.1039/c6lc00279j.
[PMID] 27045543.
2015
Microfluidic Technology: the next-generation drug discovery tool
Drug Target Review.
2(3):18-20
2014
Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology.
Lab on a chip.
14(19):3773-80
[DOI] 10.1039/c4lc00662c.
[PMID] 25099143.
2012
Electrostatic protein immobilization using charged polyacrylamide gels and cationic detergent microfluidic Western blotting.
Analytical chemistry.
84(5):2533-40
[DOI] 10.1021/ac3000013.
[PMID] 22304398.
2012
Tunable thick polymer coatings for on-chip electrophoretic protein and peptide separation.
Journal of chromatography. A.
1241:112-6
[DOI] 10.1016/j.chroma.2012.04.009.
[PMID] 22560350.
2011
Membrane-assisted online renaturation for automated microfluidic lectin blotting.
Journal of the American Chemical Society.
133(49):19610-3
[DOI] 10.1021/ja207963f.
[PMID] 22070432.
2011
Multianalyte on-chip native Western blotting.
Analytical chemistry.
83(9):3581-8
[DOI] 10.1021/ac200322z.
[PMID] 21456518.
2010
Automated microfluidic protein immunoblotting.
Nature protocols.
5(11):1844-56
[DOI] 10.1038/nprot.2010.142.
[PMID] 21030959.
2010
Parameters governing reproducibility of flow properties of porous monoliths photopatterned within microfluidic channels.
Electrophoresis.
31(14):2422-8
[DOI] 10.1002/elps.200900774.
[PMID] 20568261.
2010
Polyacrylamide gel photopatterning enables automated protein immunoblotting in a two-dimensional microdevice.
Journal of the American Chemical Society.
132(8):2512-3
[DOI] 10.1021/ja910164d.
[PMID] 20131779.
2009
Microfluidic polyacrylamide gel electrophoresis with in situ immunoblotting for native protein analysis.
Analytical chemistry.
81(19):8177-84
[DOI] 10.1021/ac901392u.
[PMID] 19731927.
2008
Confinement effects on the morphology of photopatterned porous polymer monoliths for capillary and microchip electrophoresis of proteins.
Electrophoresis.
29(14):2980-6
[DOI] 10.1002/elps.200800040.
[PMID] 18551717.
2008
Microfluidic self-patterning of large-scale crystalline nanoarrays for high-throughput continuous DNA fractionation.
Angewandte Chemie (International ed. in English).
47(34):6388-91
[DOI] 10.1002/anie.200800816.
[PMID] 18624306.
Grants
Jan 2024
ACTIVE
Leveraging Extracellular Vesicles for Gene Therapy in Hearing Restoration
Role: Other
Funding: PHARMA RES AND MANUFACTURERS OF AMERICA
Dec 2023
ACTIVE
ExoTarget Platform as a programmable delivery system
Role: Principal Investigator
Funding: NATL INST OF HLTH
Mar 2023
ACTIVE
ADVANCE: AR3T 2.0 Pilot Studies
Role: Co-Investigator
Funding: SPAULDING REHABILITATION HOSPITAL
via NATL INST OF HLTH NIBIB
Nov 2021
ACTIVE
Therapeutic Development of homogenous hMSC exosomes for Cystic Fibrosis
Role: Principal Investigator
Funding: CYSTIC FIBROSIS FOU
Aug 2020
ACTIVE
3D biomimetic lymph node engineered extracellular vesicles for understanding the heterogeneity of adaptive immunity
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Education
Postdoc, Bioengineering
2008-2011
·
University of California-Berkeley, USA,
Ph.D., Chemistry
2004-2008
·
University of Alberta, Canada,
M.S., Pharmaceutical Chemistry
2000-2003
·
Chongqing University, China,
B.S., Chemical Engineering, with Honors
1996-2000
·
Chongqing University, China,
Contact Details
Phones:
- Business:
- (352) 273-9847
Emails:
- Business:
- mhe@ufl.edu
Addresses:
- Business Mailing:
-
UF Cancer and Genetics Research Complex
2033 Mowry Rd, Gainesville, FL 32608
Office: 0458 | Lab: 0475
GAINESVILLE FL 32610