Natalia V De Moraes

Natalia V De Moraes, B. Pharm, Ph.D.

Assistant Professor

Department: Pharmaceutics
Business Phone: (407) 313-7048
Business Email: nataliademoraes@ufl.edu

About Natalia V De Moraes

Natalia de Moraes, Ph.D., is an assistant professor at the Center for Pharmacometrics & Systems Pharmacology at University of Florida College of Pharmacy. She received her B.S. in Pharmaceutical Sciences from the University of Sao Paulo, Brazil in 2006. Dr. De Moraes received her Ph.D. from the University of Sao Paulo (Brazil) under the supervision of Dr. Vera Lanchote in 2011.  Her research activities includes an internship as a graduate student at the Center for  Applied Pharmacokinetic Research (CAPKR), in the University of Manchester. Dr. De Moraes was an Assistant Professor at Sao Paulo State University (UNESP) for 9 years. She was part of the advisory board in the graduate programs of Pharmaceutical Sciences at Sao Paulo State University and Toxicology at the University of Sao Paulo. In 2020-2021, she served as a consultant to set health-based exposure limits for Cristalia Produtos Químico-Farmacêuticos Ltda (Brazil) and for Instituto BioChimico Industria Farmaceutica (Brazil). From 2019-2021, Dr. De Moraes was the local coordinator of the Iberoamerican Pharmacometrics Network (RedIF) in Brazil, alongside Prof. Teresa Dalla Costa. In 2019 and 2020, her research group was awarded with best poster and best oral presentation in the V Congress of the Brazilian Association of Pharmaceutical Sciences and in the 12th International Congress of Pharmaceutical Sciences (CIFARP), respectively, due to their work on precision dosing and pharmacometrics.

Teaching Profile

Courses Taught
2022-2023
PHA6910 Supervised Research
2023-2025
PHA6935 Selected Topics in Pharmacy
2023-2025
PHA7979 Advanced Research
2023-2025
PHA5132 Prin Drug Ther Indiv
2023
PHA6125 Introduction to Quantitative Pharmacology
2024-2025
PHA6122 Population Pharmacokinetics and Pharmacodynamics

Research Profile

Dr. De Moraes’ research interests include quantitative pharmacology approaches in the areas of chronic diseases, special populations, pharmacogenetics and drug-drug-interactions. A major emphasis has been on diabetes, obesity and bariatric surgery effect on drug metabolism and elimination. She is currently focused on the effect of obesity and Roux-en-Y gastric bypass on drug metabolizing enzyme and transporters abundance and functionality. Ultimately, population pharmacokinetic modeling and simulation and physiologically-based pharmacokinetic approach are applied to rationally design dosing strategies.

Open Researcher and Contributor ID (ORCID)

0000-0002-4389-058X

Publications

2024
Impact of obesity and Roux-en-Y gastric bypass on the pharmacokinetics of (R)- and (S)-omeprazole and intragastric pH
CPT: Pharmacometrics & Systems Pharmacology. [DOI] 10.1002/psp4.13189.
2024
Mechanistic Framework to Predict Maternal‐Placental‐Fetal Pharmacokinetics of Nifedipine Employing Physiologically Based Pharmacokinetic Modeling Approach
The Journal of Clinical Pharmacology. 64(5):568-577 [DOI] 10.1002/jcph.2404.
2024
Physiologically-based pharmacokinetic modeling of enantioselective hydroxychloroquine kinetics and impact of genetic polymorphisms
Brazilian Journal of Pharmaceutical Sciences.
2024
Rerouting cardiovascular management following gastric bypass surgery: Dose optimization of carvedilol using population-based analysis.
British journal of clinical pharmacology. [DOI] 10.1111/bcp.16129.
2023
Casearia essential oil: an updated review on the chemistry and pharmacological activities
Chemistry & Biodiversity. 20(9) [DOI] 10.1002/cbdv.202300492.
2023
Effect of Roux‐En‐Y Gastric Bypass in the Pharmacokinetics of ( R )‐Carvedilol and ( S )‐Carvedilol
The Journal of Clinical Pharmacology. 63(7):838-847 [DOI] 10.1002/jcph.2221. [PMID] 36854819.
2023
Metabolism Characterization and Chemical and Plasma Stability of Casearin B and Caseargrewiin F
Planta Medica. 89(11):1097-1105 [DOI] 10.1055/a-2078-5920.
2023
Recycled Household Ash in Rice Paddies of Bangladesh for Sustainable Production of Rice Without Altering Grain Arsenic and Cadmium
Exposure and Health. 16(1):87-99 [DOI] 10.1007/s12403-023-00539-y. [PMID] 38313597.
2023
Requirements, expectations, challenges and opportunities associated with training the next generation of pharmacometricians
CPT: Pharmacometrics & Systems Pharmacology. 12(7):883-888 [DOI] 10.1002/psp4.12970. [PMID] 37452453.
2022
Assessing the contribution of UGT isoforms on raltegravir drug disposition through PBPK modeling
European Journal of Pharmaceutical Sciences. 179 [DOI] 10.1016/j.ejps.2022.106309.
2022
CAT -21A>T Variant Alters Hydroxyurea Pharmacokinetic Parameters in Brazilian Children with Sickle Cell Anemia
Annals of Case Reports. 7(4) [DOI] 10.29011/25747754.100920.
2022
Chemometric optimization of salting-out assisted liquid-liquid extraction (SALLE) combined with LC-MS/MS for the analysis of carvedilol enantiomers in human plasma: Application to clinical pharmacokinetics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1205 [DOI] 10.1016/j.jchromb.2022.123338. [PMID] 35724550.
2022
Epidural dexamethasone showed a better analgesic profile over epidural betamethasone as adjuvant in acute neuropathic lumbar pain
International Journal of Advanced Engineering Research and Science. 9(9):385-391 [DOI] 10.22161/ijaers.99.41.
2022
Pharmacokinetics of Carboplatin in Combination with Low-Dose Cyclophosphamide in Female Dogs with Mammary Carcinoma
Animals. 12(22) [DOI] 10.3390/ani12223109. [PMID] 36428336.
2022
Therapeutic drug monitoring of gabapentin: the applicability in patients with neuropathic pain
Brazilian Journal of Pharmaceutical Sciences. 58 [DOI] 10.1590/s2175-97902022e191073.
2021
IN VITRO METABOLISM OF COPALIC AND KAURENOIC ACIDS IN RAT AND HUMAN LIVER MICROSOMES
Química Nova. [DOI] 10.21577/0100-4042.20170724.
2021
Population pharmacokinetics of gabapentin in patients with neuropathic pain: Lack of effect of diabetes or glycaemic control.
British journal of clinical pharmacology. 87(4):1981-1989 [DOI] 10.1111/bcp.14594.
2020
Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations.
Journal of clinical pharmacology. 60(8):1076-1086 [DOI] 10.1002/jcph.1603.
2020
Water Dilutes and Alcohol Concentrates Urinary Arsenic Species When Food is the Dominant Source of Exposure
Exposure and Health. 12(4):699-710 [DOI] 10.1007/s12403-019-00329-5.
2019
ABCG2 c.421C>A polymorphism alters nifedipine transport to breast milk in hypertensive breastfeeding women.
Reproductive toxicology (Elmsford, N.Y.). 85:1-5 [DOI] 10.1016/j.reprotox.2019.01.007.
2019
Acid diterpenes from Copaiba oleoresin (Copaifera langsdorffii): Chemical and plasma stability and intestinal permeability using Caco-2 cells.
Journal of ethnopharmacology. 235:183-189 [DOI] 10.1016/j.jep.2019.02.017. [PMID] 30763698.
2019
Changes in tramadol enantioselective pharmacokinetics and metabolism in rats with experimental diabetes treated or not with insulin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 128:97-102 [DOI] 10.1016/j.ejps.2018.11.032. [PMID] 30502451.
2019
Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms.
Basic & clinical pharmacology & toxicology. 124(3):266-272 [DOI] 10.1111/bcpt.13126. [PMID] 30192429.
2019
Pharmacogenomics in chronic pain therapy: from disease to treatment and challenges for clinical practice
Pharmacogenomics. 20(13):971-982 [DOI] 10.2217/pgs-2019-0066.
2019
Pharmacokinetic disposition of erythraline in rats after intravenous administration
Revista Brasileira de Farmacognosia. 29(6):773-777 [DOI] 10.1016/j.bjp.2019.07.002.
2018
Effect of inhalation exposure to toluene on the activity of organic anion transporting polypeptide (Oatp) using pravastatin as a probe drug in rats.
Xenobiotica; the fate of foreign compounds in biological systems. 48(7):734-738 [DOI] 10.1080/00498254.2017.1353717. [PMID] 28686078.
2018
The role of organic cation transporter 2 inhibitor cimetidine, experimental diabetes mellitus and metformin on gabapentin pharmacokinetics in rats.
Life sciences. 200:63-68 [DOI] 10.1016/j.lfs.2018.03.012.
2017
The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries.
European journal of clinical pharmacology. 73(8):957-963 [DOI] 10.1007/s00228-017-2243-1. [PMID] 28409297.
2016
Impact of fraction unbound, CYP3A, and CYP2D6 in vivo activities, and other potential covariates to the clearance of tramadol enantiomers in patients with neuropathic pain.
Fundamental & clinical pharmacology. 30(2):153-61 [DOI] 10.1111/fcp.12168. [PMID] 26947771.
2016
Pharmacokinetics and pharmacodynamics of rocuronium in young adult and elderly patients undergoing elective surgery.
The Journal of pharmacy and pharmacology. 68(11):1351-1358 [DOI] 10.1111/jphp.12617. [PMID] 27545305.
2015
Impact of inhalational exposure to ethanol fuel on the pharmacokinetics of verapamil, ibuprofen and fluoxetine as in vivo probe drugs for CYP3A, CYP2C and CYP2D in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 84:99-105 [DOI] 10.1016/j.fct.2015.08.002. [PMID] 26265240.
2015
Impact of visceral leishmaniasis and curative chemotherapy on cytochrome P450 activity in Brazilian patients
British Journal of Clinical Pharmacology. 80(5):1160-1168 [DOI] 10.1111/bcp.12677. [PMID] 25940755.
2014
Analysis of ibuprofen enantiomers in rat plasma by liquid chromatography with tandem mass spectrometry.
Journal of separation science. 37(8):944-9 [DOI] 10.1002/jssc.201301184. [PMID] 24482408.
2014
Analysis of rocuronium in human plasma by liquid chromatography-tandem mass spectrometry with application in clinical pharmacokinetics.
Journal of pharmaceutical and biomedical analysis. 90:180-5 [DOI] 10.1016/j.jpba.2013.11.032. [PMID] 24370612.
2014
Effects of type 1 and type 2 diabetes on the pharmacokinetics of tramadol enantiomers in patients with neuropathic pain phenotyped as cytochrome P450 2D6 extensive metabolizers.
The Journal of pharmacy and pharmacology. 66(9):1222-30 [DOI] 10.1111/jphp.12255. [PMID] 24717054.
2013
Metoprolol oxidation polymorphism in Brazilian elderly cardiac patients.
The Journal of pharmacy and pharmacology. 65(9):1347-53 [DOI] 10.1111/jphp.12109. [PMID] 23927473.
2012
Enantioselective analysis of unbound tramadol, O-desmethyltramadol and N-desmethyltramadol in plasma by ultrafiltration and LC-MS/MS: application to clinical pharmacokinetics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 880(1):140-7 [DOI] 10.1016/j.jchromb.2011.11.033. [PMID] 22173007.
2011
Simultaneous analysis of tramadol, O-desmethyltramadol, and N-desmethyltramadol enantiomers in rat plasma by high-performance liquid chromatography-tandem mass spectrometry: application to pharmacokinetics.
Chirality. 23(4):287-93 [DOI] 10.1002/chir.20914. [PMID] 21384434.
2009
Determination of mitragynine in rat plasma by LC-MS/MS: application to pharmacokinetics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 877(24):2593-7 [DOI] 10.1016/j.jchromb.2009.06.023. [PMID] 19589735.

Grants

Aug 2025 ACTIVE
UF Post-doctoral Fellowship Program – Year 2
Role: Co-Project Director/Principal Investigator
Funding: GENENTECH INC
Aug 2024 ACTIVE
UF Post-doctoral Fellowship Program – Year 1
Role: Co-Project Director/Principal Investigator
Funding: GENENTECH INC
Dec 2023 ACTIVE
Certara – UF Postdoctoral Fellowship
Role: Co-Project Director/Principal Investigator
Funding: CERTARA

Education

Ph.D. in Sciences
2011 · University of Sao Paulo
B.S. in Pharmacy
2006 · University of Sao Paulo

Contact Details

Phones:
Business:
(407) 313-7048
Emails:
Addresses:
Business Mailing:
6550 SANGER RD
ORLANDO FL 32827
Business Street:
6550 SANGER RD
ORLANDO FL 32827